abstract：:The adenylate cyclase system of an established human trichilemmoma cell line was investigated. Stimulators of human epidermal adenylate cyclase system, epinephrine, histamine, adenosine, and prostaglandin E increased cyclic AMP levels of the trichilemmoma cells. The effects of epinephrine, histamine, and adenosine wer...

journal_title：Archives of dermatological research

authors： Tsutsui M,Iizuka H,Ohkawara A,Adachi K,Kanzaki T

更新日期：1987-01-01 00:00:00

abstract：:Enhanced susceptibility to viral infections has been reported repeatedly in atopic dermatitis (AD). A difference in the capacity to produce interferons (IFN) in response to viral antigens may be the cause. In the present study we investigated the in vitro IFN production of leukocytes from AD patients in response to di...

journal_title：Archives of dermatological research

authors： Kapp A,Gillitzer R,Kirchner H,Schöpf E

更新日期：1987-01-01 00:00:00

abstract：:A 50-year-old male patient had three episodes of acrally located purpura within 12 years without any other symptoms. The first two episodes which lasted several months coincided with the intake of beta-blockers; the third episode developed after a respiratory infection. A cryofibrinogenemia was found without any evide...

journal_title：Archives of dermatological research

authors： Brüngger A,Brülisauer M,Mitsuhashi Y,Schneider BV,Bollinger A,Schnyder UW

更新日期：1987-01-01 00:00:00

abstract：:Results of previous investigations have indicated that photochemotherapy (PUVA) attacks membranes of target cells. Using the combination of a stopped-flow technique and laser irradiation we were able to prove that the fast PUVA effect is explainable solely by the membrane damage. Lymphoid cells of healthy persons or p...

journal_title：Archives of dermatological research

authors： Böhm F,Meffert H,Bauer E

更新日期：1986-01-01 00:00:00

abstract：:A low-molecular-weight proteinase inhibitor was isolated from human epidermal extracts by means of ultrafiltration, gel filtration and ion-exchange chromatography. On polyacrylamide gel electrophoresis (PAGE), the isolated fraction exhibited a single band of activity at pH 9.4, and inhibitory activity against papain a...

journal_title：Archives of dermatological research

authors： Takiuchi I,Takagi H,Goi H,Kawamura M,Higuchi D

更新日期：1986-01-01 00:00:00

abstract：:Comparative measurements of collagen synthesis as a portion of total protein synthesis were performed with fragments of peripheral neurofibromas, of skin adjacent to the tumors, and of unaffected skin from patients with neurofibromatosis (NF). No significant difference was found among these various samples. Collagen s...

journal_title：Archives of dermatological research

authors： Mühleck O,Krone W,Mao R,Weber L

更新日期：1986-01-01 00:00:00

abstract：:Renal allograft recipients were shown to have an increased incidence of warts and skin cancers. We examined 148 patients for evidence of wart virus infections and tested for papillomavirus types, which are known to be associated with human malignancies. Of the 148, 36 (24.3%) patients were afflicted with warts at the ...

journal_title：Archives of dermatological research

authors： Gassenmaier A,Fuchs P,Schell H,Pfister H

更新日期：1986-01-01 00:00:00

abstract：:Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with...

journal_title：Archives of dermatological research

authors： Furukawa F,Kashihara M,Imamura S,Ohshio G,Hamashima Y

更新日期：1986-01-01 00:00:00

abstract：:The beta-adrenergic receptors, previously shown to be present on the membranes of cultured human epidermal keratinocytes, were found to be functionally coupled to membrane-bound adenylate cyclase. Using membrane preparations, the enzyme could be activated by guanosine triphosphate (GTP), the stable GTP analog GPP(HN)p...

journal_title：Archives of dermatological research

authors： Cavey MT,Cavey D,Shroot B,Reichert U,Gazith J

更新日期：1986-01-01 00:00:00

abstract：:Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clini...

journal_title：Archives of dermatological research

authors： Schopf RE,Hoffmann A,Jung M,Morsches B,Bork K

更新日期：1986-01-01 00:00:00

abstract：:Fingernail growth was studied in 28 patients who were receiving systemic treatment with the aromatic retinoid, Ro 10-9359 known as Tigason (etretinate; AR). A group of 15 patients with psoriasis was compared with a group of 13 patients with other dermatoses which are known to have a good response to AR therapy. In the...

journal_title：Archives of dermatological research

authors： Galosi A,Plewig G,Braun-Falco O

更新日期：1985-01-01 00:00:00

abstract：:Estrone (E1)-sulfatase and dehydroepiandrosterone (DHEA)-sulfatase activities were studied in human female epidermis. Skin specimens were obtained by abdominal or plantar biopsies. The apparent Michaelis-Menten constants for E1 and DHEA sulfatases were 35.2 microM and 8.7 microM, respectively. A substrate inhibition w...

journal_title：Archives of dermatological research

authors： Prost O,Nicollier M,Laurent R,Adessi GL

更新日期：1985-01-01 00:00:00

abstract：:As congenital nevocytic nevi have an increased risk of malignant degeneration, nevus-cell involvement in blood vessels and lymphatics is of particular interest. The present histological and ultrastructural studies revealed nevus-cell nests in the walls of venules in 1 out of 11 patients with medium-sized nevi, and in ...

journal_title：Archives of dermatological research

authors： Schneider BV,Maie O

更新日期：1985-01-01 00:00:00

abstract：:Six cases of dermatofibrosarcoma protuberans were studied ultrastructurally. Biopsy material from all six cases as well as cell cultures derived from four cases were examined. In all cases, the tumor cells in vivo and in vitro were related to fibroblasts. The two cases with histiocytoid features and a small spiral pat...

journal_title：Archives of dermatological research

authors： Schmoeckel C,Albini A,Krieg T,Stets R

更新日期：1985-01-01 00:00:00

abstract：:In preparations of papillary dermis taken from clinically normal skin of patients with dermatitis herpetiformis (DH), the disappearance of granular IgA deposits induced by peptic digestion was partial at pH 4.5 and total at pH 4.1, as visualized by immunofluorescence microscopy. In a model system in which human monome...

journal_title：Archives of dermatological research

authors： Egelrud T,Bäck O

更新日期：1985-01-01 00:00:00

abstract：:T Cells from 14 patients in the active stage of bullous pemphigoid and 10 patients in the inactive stage of the disease were studied with Leu-1, Leu-2, and Leu-3 monoclonal antibodies. The proportions of total T cells and T cells expressing either helper or suppressor phenotype in the peripheral blood of patients were...

journal_title：Archives of dermatological research

authors： Ahmed AR

更新日期：1985-01-01 00:00:00

abstract：:The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) on type-IV-procollagen (basement-membrane collagen) and laminin synthesis, turnover, and secretion was studied in human A431 squamous epidermoid carcinoma cells. Type-IV procollagen and laminin were biochemically and immunologic...

journal_title：Archives of dermatological research

authors： Panneerselvam M,Sahai A,Salomon DS

更新日期：1985-01-01 00:00:00

abstract：:A suction blister device with a sensitive thermometer and with a temperature regulator was constructed. Utilizing this device, it was demonstrated that the cold challenge induces an increase in the skin temperature in cold urticaria patients during the cold challenge and a simultaneous release of histamine into the su...

journal_title：Archives of dermatological research

authors： Neittaanmäki H,Karjalainen S,Fräki JE,Kiistala U

更新日期：1984-01-01 00:00:00

abstract：:Eighteen patients with atopic dermatitis were randomly chosen for a clinical trial to compare the action of the H2 receptor antagonist cimetidine in combination with the H1 receptor antagonist chorpheniramine against the chlorpheniramine alone and against placebo. Each treatment period lasted for 4 weeks. Intensity of...

journal_title：Archives of dermatological research

authors： Frosch PJ,Schwanitz HJ,Macher E

更新日期：1984-01-01 00:00:00

abstract：:Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated wi...

journal_title：Archives of dermatological research

authors： Gruner S,Meffert H,Karasek E,Sönnichsen N

更新日期：1984-01-01 00:00:00

abstract：:In the present study, attempts were made to clarify the role of an elastase-like enzyme in Arthus reaction by using rabbit-peritoneal polymorphonuclear leukocytes (PMNs). It was first confirmed that the injection of large amounts of PMNs with antibody can increase tissue damage in reversed Arthus reaction. The five va...

journal_title：Archives of dermatological research

authors： Hamanaka K,Toki N,Tsushima H,Takasugi S

更新日期：1984-01-01 00:00:00

abstract：:The C1-inactivator plays an important role not only in the initial phases of the complement system, but also in those of the coagulation, fibrinolysis and kinin systems. The present study was concerned with the reciprocal influence of decreased C1-inactivator levels in patients with hereditary angioneurotic edema (HAN...

journal_title：Archives of dermatological research

authors： Bork K,Witzke G,Artmann K,Benes P,Böckers M,Kreuz W

更新日期：1984-01-01 00:00:00

abstract：:The effect of theophylline, an inhibitor of phosphodiesterase, on tyrosine (Tyr) transport across cell membrane was studied using cultured B-16 mouse melanoma cells. 1.5 mM Theophylline in culture medium increased Tyr uptake velocity in linear fashion up to 36 h, after which it reached a plateau at which the cells sho...

journal_title：Archives of dermatological research

authors： Saga K,Shimojo T

更新日期：1984-01-01 00:00:00

abstract：:We have examined the relationship between topical psoriasis treatment and the activity of the mixed function oxidase, aryl hydrocarbon hydroxylase (AHH), in peripheral blood monocytes and lymphocytes from 20 patients with psoriasis. These data were compared to monocyte and lymphocyte AHH activity measured in 20 normal...

journal_title：Archives of dermatological research

authors： Kraemer KH,Robinson RC,Tarone RE,Protic-Sabljic M,Gelboin HV

更新日期：1984-01-01 00:00:00

abstract：:Histochemical findings of primary and metastatic amelanotic melanomas were shown by the formaldehyde-induced fluorescence method (Falck and Hillarp). All or some of the amelanotic melanoma cells were discovered to emit green specific fluorescence. Results of the determination of 5-S-cysteinyldopa and DOPA in amelanoti...

journal_title：Archives of dermatological research

authors： Morishima T,Tatsumi F,Fukada E,Watanabe M,Nagashima N,Hanawa S

更新日期：1983-01-01 00:00:00

abstract：:A sensitive and technically simple enzyme-linked immunosorbent assay (ELISA) was developed to demonstrate circulating IgA- and IgG-class antibodies to gliadin, a component of wheat gluten. Serum samples from 24 patients with dermatitis herpetiformis (DH), 5 with coeliac disease (CD) and 75 normal controls were analyse...

journal_title：Archives of dermatological research

authors： Vainio E,Kalimo K,Reunala T,Viander M,Palosuo T

更新日期：1983-01-01 00:00:00

abstract：:The effect of skin delipidization in humans on the percutaneous penetration of hydrocortisone was investigated in a cross-over trial. The delipidizing agent was 1:1:1 trichloroethane, a common industrial organic solvent. The findings do not show any significant difference in the topical absorption of hydrocortisone wi...

journal_title：Archives of dermatological research

authors： Bucks DA,Maibach HI,Menczel E,Wester RC

更新日期：1983-01-01 00:00:00

abstract：:This study was designed in order to prove on a large-scale basis the efficacy of oral photochemotherapy (PUVA) in the prevention of polymorphous light eruption (PLE), to work out indication criteria for PUVA treatment of this disease, and to establish a simple method based on anamnestic data to differentiate UVA from ...

journal_title：Archives of dermatological research

authors： Gschnait F,Schwarz T,Ladich I

更新日期：1983-01-01 00:00:00

abstract：:A significant difference between keloids and hypertrophic scars could be demonstrated by means of acid elution of lymphoid blood cells and immunofluorescence studies. A total of 20 patients (13 patients with keloids and seven with hypertrophic scars) were investigated. All the 13 patients with keloids revealed in the ...

journal_title：Archives of dermatological research

authors： Janssen de Limpens AM,Cormane RH

更新日期：1982-01-01 00:00:00

abstract：:Three per cent boric acid incorporated in an anhydrous, water-emulsifying ointment causes no increase of boron levels in blood and urine during a period of 1-9 days after a single topical application. The same amount of boric acid incorporated in a water-based jelly does cause an increase in blood and urine levels, be...

journal_title：Archives of dermatological research

authors： Stüttgen G,Siebel T,Aggerbeck B

更新日期：1982-01-01 00:00:00

abstract：:Abnormal dermal deposition of elastic fibers is the earliest and most striking effect of prolonged sun exposure (solar elastosis). The hyperplastic fibers are usually ascribed to ultraviolet (UV) rays. Nonetheless, other portions of the solar spectrum may play contributing roles. Heat, for example, enhances experiment...

journal_title：Archives of dermatological research

authors： Kligman LH

更新日期：1982-01-01 00:00:00

abstract：:Quantitative studies of the aerobic flora of seven skin sites in 16 volunteers were repeated after 3 months. The total aerobic densities of the sites differed, male carried more organisms than females and also more biotypes. Qualitative differences in the flora could be detected. ...

journal_title：Archives of dermatological research

authors： Marples RR

更新日期：1982-01-01 00:00:00

abstract：:In dermatophytosis, there is exocytosis of polymorphonuclear leukocytes (PMNs) toward the fungus-laden horny layer. To analyze this mechanism, we studied in vitro leukotactic properties of epidermal extracts prepared from lesions of experimental Trichophyton mentagrophytes infection in guinea pigs as well as fungus-de...

journal_title：Archives of dermatological research

authors： Tagami H,Natsume N,Aoshima T,Inoue F,Suehisa S,Yamada M

更新日期：1982-01-01 00:00:00

abstract：:HLA types were determined in 19 patients and 9 healthy members of 2 Danish families with hereditary angioneurotic edema. The study revealed no connections between hereditary angioneurotic edema and the HLA system. ...

journal_title：Archives of dermatological research

authors： Eggert J,Zachariae H,Svejgaard E,Svejgaard A,Kissmeyer-Nielsen F

更新日期：1982-01-01 00:00:00

abstract：:To investigate the turnover of complete junctional membrane areas ("domain turnover"), psoriatic epidermis, keratoacanthoma, and squamous cell carcinoma were studied with an electron microscope and compared with the normal epidermis. Three types of domain turnover of junctions were observed. First, the uptake of intac...

journal_title：Archives of dermatological research

authors： Mahrle G

更新日期：1982-01-01 00:00:00

abstract：:The aim of this investigation was to determine whether volumetric changes occurred in differentiating layers of stratified squamous epithelium. Samples of cheek pouch mucosa from 5 hamsters were obtained, prepared for electron microscopy using carefully controlled methods, and electron micrographs obtained from define...

journal_title：Archives of dermatological research

authors： White FH,Gohari K

更新日期：1982-01-01 00:00:00

abstract：:A procedure measuring the ornithine decarboxylase (ODC) activity and polyamine formation of intact neonatal mouse epidermal cells in culture has been developed and tested. Basal cells prepared from neonatal mouse epidermis were plated on round 15-mm Lux coverslips, placed in Costar 24 well culture clusters and grown a...

journal_title：Archives of dermatological research

authors： Roseeuw DI,Duell EA,Marcelo CL

更新日期：1982-01-01 00:00:00

abstract：:Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased i...

journal_title：Archives of dermatological research

authors： Guarrera M,Parodi A,Cipriani C,Divano C,Rebora A

更新日期：1982-01-01 00:00:00

abstract：:Two male patients with longstanding contact sensitivity to chromium were treated with PUVA. One patient, suffering from concomitant photosensitivity, reacted very favorably; his skin lesions cleared and light tolerance increased. This was paralleled by a decrease in the photopatch test reactivity and by the extinction...

journal_title：Archives of dermatological research

authors： Jansén CT,Viander M,Kalimo K,Soppi AM,Soppi E

更新日期：1981-01-01 00:00:00

abstract：:Polymorphonuclear leukocytes from patients with psoriasis demonstrated a significantly enhanced chemotactic responsiveness to zymosan-activated human serum as compared to granulocytes from healthy volunteers. Furthermore, psoriatic peripheral blood mononuclear cells stimulated with concanavalin a produced an increased...

journal_title：Archives of dermatological research

authors： Csató M,Dobozy A,Hunyadi J,Kenderessy SA,Simon N

更新日期：1981-01-01 00:00:00